Events
GLEN D. DOBBEN, MD PHYSICIAN-INNOVATOR-EDUCATOR
Neuroradiologist Dr. Glen D. Dobben, professor emeritus of radiology,
died Jan. 2, 2005. A renowned educator, clinical and researcher, he
had taught hundreds of radiologists and residents in the last 42 years.
He came to UIC as a full professor in 1969 from the University of
Chicago and the Cook County Graduate School of Medicine.
Dr. Dobben's
initial clinical studies concentrated on improving the practice of
pneumoencephalograhy. Later he developed the "CT-Pneumo-Cisternography"
procedure for evaluation of CP Angle lesions with virtually no added
risk of morbidity and minimal patient discomfort.
With one of
the first CT scanners in the Chicago area, Dr. Dobben collaborated
with Drs. Valvassori and Mafee on cerebral blood-flow measurements,
developing dynamic charting of both forebrain and hindbrain blood-flow
circulation using CT techniques. General Electric adopted his technique
as the bases for its commercial software programs - now used worldwide
for CT-cerebral perfusion studies. Dr. Dobben presented numerous lectures
in the United States, Europe and Japan on the subject.
As the first
neuroradiologist in Chicago, he was also involved in percutaneous
introduction of metal coils for occlusion of AV malformations and
obliteration of cerebral aneurysms in collaboration with Prof. Sean
Mullan at the University of Chicago. Today this technique is widely
used in the treatment of subarachnoid and other intracranial vascular
hemorrhages. Dr. Dobben collaborated with Dr. Valvassori, also a Professor
of Radiology UIC and one of the world's experts in radiographic evaluation
of middle and inner ear structures. Dr. Dobben's contribution in this
field was in CT densitometry of the cochlea in temporal bone. This
permits the diagnosis of otosclerosis and today it remains the only
way to radiologically confirm the pathology in this disease process.
Dr. Dobben also started an annual meeting, ?International Special
Procedure Conference for Radiology Technologists," with 300 participants
each year. He is survived by his wife, Barbara, six children, and
his sister Marjorie.
FEATURED DOBBEN
SPEAKER: KEITH THULBORN, MD, PHD
Keith Thulborn,
MD, PhD, came to UIC in 2000 as professor of radiology, physiology
and biophysics and is director of the Center for Magnetic Resonance
Research. Dr, Thulborn has made a wide range of fundamental contributions
to functional neuroimaging technology and clinical applications. Under
his leadership, UIC has completed the world's first 9.4T MRI Scanner
for human functional neuroimaging, which promises to provide unprecedented
and anatomical levels.
THE GLEN DOBBEN,
MD, MEDICAL EDUCATION FUND
The Glen D.
Dobben, MD, Medical Education Fund was established by colleagues,
former trainees and friends to commemorate Dr. Dobben's lifelong commitment
to patient care, innovation and education. This permanently endowed
fund provides a fitting tribute to Dr. Dobben's life and work. Income
from the endowment will be used to produce a yearly lecture hosted
be the Center for MR research in cooperation with the Department of
Radiology at the University of Illinois at Chicago.
Cheque Presenting Ceremony from Washington Square Health Foundation
to College of Medicine for Visual Science.
Cheque Presenting
Ceremony from Washington Square Health Foundation to College of Medicine
for Visual Science. (From L to R) Dr. Jeffrey N.Bloom, MD. Dr. Janet
P. Szlyk, Ph.D. Howard Nochumson, Executive Director, Washington Square
Health Foundation, Inc. Dr. Michael D. Bailie, Associate Dean, Faculty
Affairs. Dr. Jose S. Pulido, MD, Professor and Head, Dept of Opthalmology.
Dr Keith R. Thulborn, Director, Center for MR Research.
Chicagoland Symposium, April 4 2003,
Functional MRI of the Brain in Health and Disease
| A. Vania Apkarian, PhD |
Northwestern University |
| James Houk, PhD |
Northwestern University Medical School |
| Art Kramer, PhD |
University of Illinois at Urbana-Champaign |
| Deborah Little, PhD |
University of Illinois at Chicago |
| Peter Reber, PhD |
Northwestern University |
| Steven Small, MD, PhD |
University of Chicago |
| Ana Solodkin, PhD |
University of Chicago |
| David Vaillancourt, PhD |
University of Illinois at Chicago |
- Topic Highlights
- Multi-modal Imaging of the Brain in Chronic Pain
- The Cerebellum- Its Role in Motor and Cognitive Function
- Aging, Fitness, and Neurocognitive Function
- Learning in Normal and Injured Brains
- Functional Processes Engaged in the Visual and Non-Visual
Control of Force
- Fine Modulation in Network Activation during Motor Execution
and Different Types of Motor Imagery
- Stroke Rehabilitation
- Memory
- Schedule
9:00am Welcome and Introduction
Keith Thulborn, M.D., Ph.D.
Professor and Director, Center for Magnetic Resonance Research
at UIC9:15am The Cerebellum -- it's role in Motor and
Cognitive Function
James Houk, Ph.D.
Professor of Physiology
Northwestern University Medical SchoolThe cerebellum's important
function is to regulate neural signals in other parts of the brain,
and it does this through loops of interaction. Currently, we know
most about its regulatory actions on the populations of neurons
that command movement and posture. However, the size of the cerebellum
in mammals parallels the evolution of the cerebral cortex, and
the newest regions of the cerebellum regulate higher cerebral
processes for motor planning, cognition and problem solving.9:45am
Aging, Fitness and Neurocognitive Function
Art Kramer, Ph.D.
Professor of Psychology and Neuroscience
Department of Psychology, Campus Neuroscience Program, Beckman
Institute
Department of Kinesiology, Institute of Aviation
University of Illinois at Urbana ChampaignI will briefly review
the animal literature on the influence of fitness training on
learning, brain function and structure (at the molecular and cellular
levels). I'll then review the human literature on fitness training
and cognitive function. Finally I'll conclude with a discussion
of some of our recent research on the influence of fitness differences
and fitness training on human brain structure and function.10:15am
Discussion10:30am Coffee Break10:45am Functional
Recovery from Corticospinal Tract Stroke
Steven Small, M.D., Ph.D.
Associate Professor of Neurology
University of ChicagoReference: Small, S. L., Hlustik, P., Noll,
D. C., Genovese, C., & Solodkin, A. (2002). Cerebellar hemispheric
activation ipsilateral to the paretic hand correlates with functional
recovery after stroke. Brain, 125(Pt 7), 1544-1557.An experimental
lesion in the primary motor or sensory cortices in monkeys leads
to functional reorganization in areas surrounding the lesion or
in contralateral homologous regions. In humans, task-dependent
brain activation after motor stroke seems to be multifocal and
bilateral. Although many active structures are seen after stroke,
their roles are unclear. For instance, the uninjured primary motor
cortex may play a significant role in recovery or may be associated
with mirror movements. Other motor areas, particularly those outside
the affected middle cerebral artery distribution, have also been
thought to play such a role, including the medial pre-motor areas
and both cerebellar hemispheres. The lateral pre-motor areas might
also contribute but the demarcation of primary motor and pre-motor
cortices is not trivial. It is not known from existing studies
how brain activation relates to behavioural change over the time
course of recovery. We used functional MRI (fMRI) to study 12
patients longitudinally over the first 6 months of stroke recovery.
All subjects had acute stroke causing unilateral arm weakness
and had some ability to move the impaired hand within 1 month.
Each patient had both motor testing and fMRI during finger and
wrist movements at four points during the observed period. Six
of these patients showed good motor recovery, whereas the other
six did not. The imaging results support a role for the cerebellum
in mediating functional recovery from stroke. The data suggest
that patients with good recovery have clear changes in the activation
of the cerebellar hemisphere opposite the injured corticospinal
tract. Patients with poor recovery do not show such changes in
cerebellar activation. No other brain region had a significant
correlation with recovery. Interestingly, activation in the cerebellum
ipsilateral to the injury increases transiently after stroke,
independently of the success of recovery. The present work suggests
a possible link between cerebellar activation and behavioural
recovery from hand weakness from stroke. The underlying mechanism
is not known, but it could relate to haemodynamic changes such
as diaschisis or to the postulated role of the cerebellum in motor
skill learning.11:15am The Progression of Dynamic Changes
in Activation Patterns during Learning
Deborah Little, Ph.D.
Research Associate, Center for Magnetic Resonance Research
University of Illinois at ChicagoLearning has traditionally been
characterized by dramatic changes in behavioral performance on
a given task. The use of functional imaging has allowed for investigation
into the biological changes that develop with this increased knowledge.
Data will be presented that demonstrate the biological changes
occurring throughout the learning process from the unlearned to
expert state.11:45am Discussion 12:00 LunchModerator:
Greg Miller, Ph.D., Professor of Psychology, Department of Psychology,
UIUC1:30pm Functional Neuroimaging of Human Memory
Paul J. Reber, Ph.D.
Assistant Professor, Department of Psychology
Northwestern University2:00pm Modulation in Network
Activation during Motor Execution & Motor Imagery
Ana Solodkin, Ph.D.
Assistant Professor in Neurology
University of ChicagoMotor imagery is the "mental rehearsal
of motor acts without overt movements". Motor imagery include
either a visual representation (visual imagery) or mental simulation
of movement, associated with a kinesthetic feeling (kinetic imagery).
Previous work with brain imaging suggests that the total volume
and regional distribution of brain activation differs when comparing
movement execution (E) with either type of imagery. However, it
remains unknown how these three tasks compare to each other. Furthermore,
we do not know how the activation patterns in execution, KI, and
VI relate to each other when evaluated in terms of network organization.
The present study focuses on how the motor system organizes information
in functional networks to establish these motor behaviors. Using
fMRI, the study addresses the regional activation patterns associated
with them and also uses Structural Equation Modeling to determine
effective connectivity among relevant areas of the network for
each condition. The data showed that overt movements produce widespread
activation throughout the parieto-frontal circuits, whereas during
imagery, activation is more confined. Of note, kinetic imagery
and execution appear to be generated by very similar underlying
circuits whereas visual imagery is substantially different. However,
in the three conditions, effective connectivity shifts to different
connections giving to each condition a particular "motor
network print".2:30pm Discussion 2:45pm Coffee
BreakModerator: Todd Parrish, Ph.D., Research Physicist, Northwestern
University Medical School3:00pm Multi-modal Imaging
the Brain in Chronic Pain
Vania Apkarian, Ph.D.
Associate Professor of Physiology, Anesthesia, and Surgery
Neuroscience Institute, Cognitive Brain Mapping Group, and Lurie
Cancer Center
Northwestern University Medical SchoolThe talk will outline our
approach to delineate brain mechanisms for chronic pain. Functional
MRI is used in conjunction with real-time ratings of subjective
pain perception to delineate brain activity related to spontaneous
fluctuations of chronic pain in chronic back pain patients. MR
spectroscopy is used to identify brain regional chemistry abnormalities
and related to the subjective pain parameters. Based on these
studies we examine cognitive abilities of chronic pain patients
and identify a specific cognitive deficit. If time permits I will
go over the mechanisms that we think underlie the transition from
acute to chronic pain states.3:30pm Functional Processes
in the Visual & Non-Visual Control of Force
David E. Vaillancourt, Ph.D.
Research Associate
School of Kinesiology, College of Applied Health Sciences
University of Illinois at ChicagoThe network used during force
control was separated using subtractive logic into four distinct
processes that spanned multiple brain regions. A systematic topography
of visuomotor and motor processes is described for the prefrontal
cortex, thalamus, putamen, premotor cortex, parietal cortex and
the cerebellum. The findings are contrasted with present models
of perception-action coupling that primarily rely on the parietal
and premotor network.4:00pm Discussion & Review4:15pm
Close
- Location
University of Illinois at Chicago
Molecular Biology Research Building (MBRB)
900 South Ashland Avenue, Room 107
Chicago IL 60612DirectionsVia CTA bus
Take the #9 Ashland Ave or #37 Sedgwick Ave bus to the Ashland/Taylor
Intersection stop. Walk north to the entrance. By CTA Train
Take the 54/Cermak Blue Line train to the Polk Street stop. Walk
east two blocks to Ashland Avenue. Turn right and walk south to
the entrance.By Car
From the north, take the Kennedy Expressway to the Eisenhower
Expressway west bound and keep to the right; take the second exit
from the Eisenhower Expressway, which is Ashland Avenue; take
Ashland Avenue south to 900 South Asland Avenue. The entrance
is on the right.
From the south, take the Dan Ryan Expressway and exit on Roosevelt
Road (1200 south); go west on Roosevelt Road to Ashland Avenue;
then go north on Ashland Avenue to 900 South Ashland Avenue. The
entrance is on the left.From the west, take the Eisenhower Expressway
to the Ashland Avenue exit; take Ashland Avenue south to 900 South
Ashland Avenue. The entrance is on the right. From the east, take
Harrison Street or Roosevelt Road west to Ashland Avenue. It you
take Harrison Street, go south on ashland to 900 South Ashland
Avenue, or from Roosevelt Road go north on Ashland to 900 South
Ashland Avenue.Map
Hotel
Accommodation
Hyatt University Village
625 South Ashland Avenue
Chicago IL 60607 Located one block south of MBRB. Please make
reservations online
or at (312) 491-1234.
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