Keith R. Thulborn, MD, PhD
Professor of Radiology, Physiology and Biophysics
Director of the MR Research Program
Chief of Cross-Sectional Neuroradiology
Center for MR Research
1801 W.Taylor St.
RM 1307 OCC (M/C 707)
Chicago, IL 60612
Phone: (312) 355-3755
Fax: (312) 355-3085
Email: kthulbor@uic.edu
Research
My research entails the development
of magnetic resonance imaging technology for functional, physiological
and metabolic investigations of the normal human brain and in the
setting of pathology. Clinical applications include investigations
of cognitive function at the acute, subacute and rehabilitation stages
of stroke, dementia as related to Alzheimer's disease and presurgical
planning for arteriovenous malformations and brain tumors. Research
applications are geared towards producing a biochemical model of brain
function.
Recent clinical progress includes
mapping of brain function in the setting of stroke recovery with BOLD
contrast fMRI, clinical development of a rapid acute stroke protocol
that includes application of sodium imaging to map tissue viability
in the setting of acute stroke for planning strokectomy and serial
imaging of large arteriovenous malformations during staged embolization
intervention.
Technological progress towards
higher spatial and temporal resolution for metabolic imaging is being
made through the development of the highest field human MR scanner
at 9.4 Tesla. This scanner is to be housed in a new building contiguous
with the existing 3.0 Tesla research scanner and the two1.5 Tesla
clinical scanners. This project represents a considerable institutional
commitment to MR technology in a uniquely integrated research and
clinical environment. Technology transfer is facilitated through proximity
of interdisciplinary teams of investigators from clinical, basic science,
and engineering departments, with out-reach through high-performance
computer links to investigators on the Urbana/Champaign campus.
Clinical Cross-Sectional Neuroradiology
The MRI Center sees approximately
18 patients for imaging and spectroscopic studies of the brain and
spine and 6 patients for imaging of other body areas each day. Patients
vary from newborns to geriatric patients. Diseases range from developmental
delay, congenital abnormalities, metabolic defects, epilepsy and infections
though to trauma, neoplasia, stroke and dementia.
Cross-sectional imaging is separated
from the neurointerventional service for improved patient care through
specialized faculty and resources but close collaboration is maintained
through patient care and research.
Recent Publications
- Thulborn KR, Carpenter PA,
Just MA . Plasticity of language-related brain function during recovery
from stroke. Stroke 1999;30:749-754.
- Thulborn KR, Gindin TS, Davis
D, Erb P. Comprehensive MRI Protocol for Stroke Management: Tissue
Sodium Concentration as a Measure of Tissue Viability in a Non-Human
Primate Model and Clinical Studies. Radiology 1999;139:26-34.
- Thulborn KR, Shen GX. An integrated
head immobilization system and high performance RF coil for fMRI
of visual a paradigms at 1.5Tesla. J Magn Reson 1999;139:26-34.
- Carpenter PA, Just MA, Keller
TA, Eddy WF, Thulborn KR. Time course of fMRI-activation in language
and spatial networks during sentence comprehension. NeuroImage 1999
10;216-224.
- Berman RA, Colby CL, Genovese
CR, Voyvodic JT, Luna B, Thulborn KR, Sweeney JA. Cortical networks
subserving pursuit and saccadic eye movements in humans: a fMRI
study. Human Brain Mapping 1999 8;209-225.
- Thulborn KR, Davis D, Erb P,
Strojwas M, Sweeney JA. Clinical fMRI: implementation and experience.
NeuroImage. 1996; 4: S101-S107
- Thulborn KR. A BOLD move for
BOLD fMRI. Nature 1998;4(2):155-156
- Thulborn KR, Voyvodic J, Chang
S, Strojwas M, Sweeney JA. New approaches to cognitive function
by high field functional MRI. In: Yuasa T, Prichard JW, Ogawa S,
(eds) Current Progress in Functional Brain Mapping: Science and
Applications Nishimura/Smith-Gordon, Niigata/London, 1998; pp15-23
- Thulborn KR. Quality assurance
in clinical and research echo-planar functional MRI. In: Medical
Radiology - Diagnostic Imaging and Radiation Oncology. Vol: Functional
MRI. Eds. Moonen C. Bandettini P. Springer-Verlag Berlin 1999 chap
28, pp337-346.
- Booth JR, MacWhinney B, Thulborn
KR, Sacco K, Voyvodic J, Feldman HM. Functional organization of
activation patterns in children: Whole brain fMRI imaging during
three different cognitive tasks. Prog Neuro-Psychopharmacol Biol
Psychiat 1999;23:669-682.
- Thulborn KR. Why Neuroradiologists
should consider Very High Field Magnets for Clinical Applications
of fMRI? Topics in Magnetic Resonance Imaging 1999;10:1-2.
- Thulborn, K.R., Gisbert, A.
Clinical Applications of Mapping Neurocognitive Processes in the
Human Brain with functional MRI. In: Functional Magnetic Resonance
Imaging of the Brain: Methods for Neuroscience. Eds. Matthews, P.M.,
Jezzard, P., and Smith, S.M., Oxford University Press Oxford. 2000,
pp XXX (in press).
- Thulborn KR, Martin C, Voyvodic
J. fMRI using a visually guided saccade paradigm in Alzheimer's
disease. AJNR Am J Neuroradiol 2000 21:524-531.
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